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Yuka Someya Selected Research

4- fluoro- 1- (((4- methyl- 1- (methylsulfonyl)piperidin- 4- yl)amino)acetyl)pyrrolidine- 2- carbonitrile

11/2009Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.
3/2009Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
3/2009Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
2/2009Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice.
7/2008ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.
5/2008Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo.

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Yuka Someya Research Topics

Disease

6Type 2 Diabetes Mellitus (MODY)
03/2009 - 07/2008
4Glucose Intolerance
11/2009 - 12/2008
3Hypoglycemia (Reactive Hypoglycemia)
11/2009 - 05/2008
1Heart Failure
04/2021
1Myocardial Infarction
04/2021
1Hyperglycemia
03/2009
1Body Weight (Weight, Body)
02/2009

Drug/Important Bio-Agent (IBA)

64- fluoro- 1- (((4- methyl- 1- (methylsulfonyl)piperidin- 4- yl)amino)acetyl)pyrrolidine- 2- carbonitrileIBA
11/2009 - 05/2008
4Hypoglycemic Agents (Hypoglycemics)IBA
03/2009 - 07/2008
3Blood Glucose (Blood Sugar)IBA
04/2021 - 02/2009
3Dipeptidyl-Peptidase IV InhibitorsIBA
03/2009 - 07/2008
2Streptozocin (Streptozotocin)FDA Link
02/2009 - 12/2008
2Insulin (Novolin)FDA Link
02/2009 - 12/2008
2Niacinamide (Nicotinamide)FDA LinkGeneric
02/2009 - 12/2008
2Glucose (Dextrose)FDA LinkGeneric
01/2009 - 12/2008
1Gliclazide (Diamicron)IBA
11/2009
1LipidsIBA
02/2009
1Hemoglobin AIBA
02/2009
1CholesterolIBA
02/2009
1Fatty Acids (Saturated Fatty Acids)IBA
02/2009
1Triglycerides (Triacylglycerol)IBA
02/2009
1Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
02/2009
1Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA
01/2009
1Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA
01/2009
1Glucagon-Like Peptide 1 (GLP 1)IBA
01/2009

Therapy/Procedure

1Glycemic Control
03/2009
1Therapeutics
03/2009